The key issue often associated with aquatic food production is the production of large amount of sidestreams which creates a huge loss of nutrients if discarded irresponsibly. Seafood supply is confronting numerous challenges such as population-induced demand pressure, changing consumer preferences, overfishing, bycatch, species depletion, aquatic pollution, global warming, biodiversity alterations, and acidification of ocean water (Venugopal 2022). The European Commission ( 2018) predicts that by 2050, the demand for seafood may increase by up to 60% along with the increasing global population, which is expected to reach 9.8 billion by that time. In 2020, the total world seafood production of 179.8 million metric tons (MT) contributed around 157.4 MT directly for human consumption (at 20.2 kg per capita rate) (FAO 2022). Seafood is an essential component of most food security programs being a comparatively cost-effective protein resource worldwide. This review attempts to provide a route map for the tuna industry for achieving the circular blue-bioeconomic objectives and reorient the irregular utilization pattern into a sustainable and inclusive path. Using different nutrient recovery technologies like enzymatic hydrolysis, chemical processing, and green technologies, various categories of product value chains can be created in line with the conventional processing industry. Different products such as fish meal, protein hydrolysates, collagen, enzymes, oil, and bone powder can be produced from tuna sidestreams. The huge volume of solid and liquid sidestreams generated during the processing stages of tuna is creating environmental and socioeconomic challenges in coastal areas. Tuna meat is rich in essential nutrients such as amino acids, polyunsaturated fatty acids (PUFA), and trace minerals. Finally, a process for extraction and separation of the aforementioned glycosides by means of the high-pressure phase equilibrium phenomenon is discussed.Tuna is an economically significant seafood, harvested throughout the world, and is heavily traded due to its high nutritional quality and consumer acceptance. Then, experimental results are reported for the partitioning of small amounts of cardiac glycosides (digitoxin and digoxin) on coexisting liquid phases in the high-pressure, three-phase, vapor-liquid-liquid equilibrium of the ternary system of "near critical" CO(2) + water + 1-propanol, at 313 K and 333 K. In this study, basic fluid phase equilibrium phenomena are briefly described. Making use of this phenomenon in process development first requires research on the phase split phenomenon and, second, research on the feasibility of biomolecule extraction and separation. This phase split results in two hydrophilic liquid phases. g., an alcohol) reveals a liquid phase split, when it is pressurized with a "near-critical" gas (i.e., a substance which at ambient conditions is a gas, near its critical temperature). This investigation examines phase equilibrium phenomena that can be used to create two water-like solvents for liquid-liquid extraction in downstream processing in biotechnology: a completely miscible, binary liquid mixture of water and a hydrophilic organic solvent (e.
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